When using Minecraft with VR (using a Samsung Odyssey Windows Mixed Reality headset specifically, no other devices confirmed beyond WMR), the menu items can only be activated once before the interaction stops completely.

To duplicate this, load up Minecraft and get into the VR living room. From here, if you were to toggle the perspective, you can shift to and from the VR room to the game just fine. But if you are in the game (not on the couch) try to open one of the menu screens (game menu, inventory, chests, etc.), the first attempt will open but additional attempts will not display. I haven't seen any warnings or errors. I haven't been able to get the menu's to display until force quitting the exe and booting the game fresh. If there are any logs that would be helpful, I would be happy to attach them.

The VR controllers are responding and working as expected beyond opening these types of screens. (Breaking blocks, placing blocks, movement, and interacting with the HUD on the left hand)

A few people have run into this issue as well, the only mention I have found is on this forum. I don't know if it is specific to this release or specific to the WMR headsets.

Update 1: Thanks to @Chrisstovla, it has been determined (and I was able to confirm as well) that turning off "screen animations" in the video settings will allow the menus to open and close as expected. Hopefully, this additional information will help resolve the issue!